Endocrine Abstracts

Introduction: Metabolic Syndrome (MetS) represents a cluster of vascular risk factors related to insulin resistance such as abdominal obesity, hypertension, and glucose and lipid dysregulations. Multiple studies suggest an increasing metabolic risk in psychiatric patients. ObjectivesWe aim to assess epidemiological and clinical features of MetS in a Mediterranean psychiatric population. MethodsWe conducted a descriptive cross-sectional study involving 126 patients attending th...

Introduction: Mortality among patients with schizophrenia and psychotic disorders(SAPD) is two to threefold higher than in the general population and is widely attributed to cardiovascular and metabolic morbidity.Objectives: We aim to highlight the metabolic profile of Mediterranean patients diagnosed with SAPD.Methods: We conducted a descriptive and analytical cross-sectional study involving 55 patients who attended the psychiatry...

Introduction: Insulinoma is a rare neuroendocrine tumor with an incidence of 1 to 4 per million person-years. It is the most frequent endocrine tumor of the pancreas and is revealed by a spontaneous hypoglycemia. This study aimed to determine the clinical characteristics, diagnostic workup, and outcome of patients with insulinoma.Methods: This is a descriptive, retrospective study including patients with confirmed insulinoma collected over a 32-year peri...

Introduction: Acromegaly is a chronic, slowly progressing disease caused in most cases by growth hormone (GH)- producing pituitary adenoma. This rare disorder is associated with a spectrum of various clinical manifestations and treatment outcomes differ between patients. The aim of this study was to evaluate the impact of adenoma size on comorbidities and biochemical status at the diagnosis of disease.Methods: This is a one-centre cohort study conducted ...

Background and Aims: Acromegaly is a rare condition caused by an excessive secretion of growth hormone (GH) and insulin-like growth factor1 (IGF-1), which are responsible for exaggerated somatic growth and distorted proportions. The objective of the current work was to investigate the clinical and demographic features of acromegaly in Mediterranean patients.Patients and Method: From 1997 to 2021, 29 patients with acromegaly were diagnosed and followed up...

Introduction: Perrault syndrome (PS) is a rare disease characterized by the association of a premature ovarian failure (with primary or secondary amenorrhea) and a sensorineural deafness. In this context we report the case of three patients presenting the association of these two anomalies.Cases: We report the cases of three females, including two sisters from a consanguineous marriage, aged 21, 16 and 23 years, respectively. The two cardinal signs of th...

Introduction: Polyglandular autoimmune syndrome (PAS) are uncommon constellations of autoimmune diseases characterized by the occurrence of two or more auto-immune endocrine diseases in the same individual.Patients and methods: It is a case-control study about 108 cases for 120 healthy subjects recruited as the control group. We aimed to study the polymorphism of the HLA class-II genes of patients compared to that of healthy subjects so as to identify th...

Background and Aims: The incidence of adrenal incidentaloma(AI) has been rising sharply due to the increased use of radiologic imaging. It shows evident variation with age, with the majority of the cases presenting in the 5th to 7th decade of life. This study aims to assess the prevalence of AI and its radiological features and hormonal profiles in the geriatric population.Patients and Method: We conducted a retrospective descriptive study including 177 ...

Background and Aims: Numerous studies have suggested that metabolic syndrome (MetS) is related to adrenal incidentaloma (AI) in young adults. Limited data about MetS in geriatric patients diagnosed with AI are available, despite the high incidence of this adrenal disease in the elderly. This study aims to assess the prevalence of MetS and its associated factors in aged patients harboring AI.Patients and Method: We conducted a retrospective, comparative, ...

Introduction: Long-term glucocorticoid replacement therapy in patients with Addison disease has been linked to an increased cardiovascular risk and consequent mortality. Our objective was to determine the frequency of dyslipidemia in patients with Addison disease and its potential predictive factors.Patients and methods: This was a cross-sectional study, performed in the department of endocrinology in Hedi Chaker hospital –Sfax –Tunisia. Fifty ...